UW Genome Sciences

Faculty Search

Open Rank and Assistant Professor positions. Application deadline is December 4.

Graduate Program

Our application deadline is December 1.

DeWitt Lab

Replaying germinal center evolution on a quantified affinity landscape

Fowler Lab

Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects

Distinguished Teaching Award

Hannah Jordt receives UW Distinguished Teaching Award

National Academy of Sciences

Jesse Bloom elected to the National Academy of Sciences

National Academy of Medicine

Jay Shendure elected to National Academy of Medicine

Eichler Lab

Complete sequencing of ape genomes.

Welcome to the Department of Genome Sciences

Our goal is to address leading edge questions in biology and medicine by developing and applying genetic, genomic and computational approaches that take advantage of genomic information now available for humans, model organisms and a host of other species. Our faculty study a broad range of topics, including the genetics of E. coli, yeast, C. elegans, Drosophila, and mouse; human and medical genetics; mathematical, statistical and computer methods for analyzing genomes, and theoretical and evolutionary genetics; and genome-wide studies by such approaches as sequencing, transcriptional and translational analysis, polymorphism detection and identification of protein interactions.

Upcoming Events

November 16, 2026 3:00 pm – 4:00 pm

Foege Auditorium

Dissertation Defense:

Leah Anderson

Dunham Lab | Ph.D. in Genome Sciences

“Experimental evolution as a framework for understanding genetic adaptation and engaging students in scientific research”

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November 18, 2026 11:30 am – 12:30 pm

Health Sciences D-209

Dissertation Defense:

Alexis Chang

Villén Lab | Ph.D. in Genome Sciences

“Phosphotyrosine proteomics for the masses and beyond model organisms”

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November 18, 2026 3:30 pm – 4:30 pm

Foege Auditorium

GS Seminar:

Dr. Adam Phillippy

Johns Hopkins University

talk will be recorded

“Complete telomere-to-telomere genomes as a foundation for predictive genomics”

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EVENTS CALENDAR

Research Highlights

Human acrocentric chromosome short-arm de novo mutation and recombination

Current and former members of the Eichler Lab are authors on a paper in Cell.

A telomere-to-telomere map of somatic mutation burden and functional impact in a cancer

Stergachis Lab members are authors on a paper in Cell. | UW Medicine Newsroom

Somatic epimutations cap genetic determinism in the human diploid chromatin epigenome

Stergachis Lab members are authors on a paper in Cell.

A DNA Typewriter records the cell lineage history of a mouse, from zygote to late organogenesis

Shendure Lab members are authors on a paper in Science. | UW Medicine Newsroom

Telomeric amplicons of SUL1 and Y’ in yeast are generated by microhomology-mediated break induced replication occurring in cis

Brewer-Raghuraman Lab and Dunham Lab members are authors on a paper in PLOS Genetics.

Mutational bias and local genome context constrain adaptive paths in experimental evolution

Current and former Dunham Lab members are authors on a paper in Genetics.

Vibe Coding Moves Beyond the Proteomics Prototype

The MacCoss Lab is featured in an article in The Analytical Scientist.

Prioritizing Peptides for Targeted Mass Spectrometry Experiments Using Deep Learning

Yash Sonthalia and Bo Wen are lead authors on publication in Journal of Proteome Research.

3D epigenome of glial cell types in developing human cortex

Current and former Hawkins Lab members are authors on paper in Nature.

Evidence for G6PD variant classification from multiplexed functional assays

Current and former Dunham and Fowler Lab members are authors on paper in Genome Biology.