UW Genome Sciences

 

Wednesdays, 3:30, Foege Auditorium (Foege S-060) unless otherwise noted

UW Genome Sciences brings leading researchers from a broad spectrum of scientific areas to campus to discuss the latest advances in genetics, genomics, proteomics, computational research and related emerging tools and technologies.

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Not all seminars are recorded, but those which are will be posted to the past seminars page and deleted after two weeks. Please note that a current UW NetID is required to access past seminar recordings.

Summer 2022

Thursday, 6/23/22 - Dr. Nicolas Altemose | UC Berkeley
"Long-read sequencing methods for studying centromere organization, evolution, and function"
3:30, Foege Auditorium | remote viewing option | flier | talk will be recorded

Reference genome assemblies have historically excluded repetitive satellite DNA sequences found within and near centromeres, limiting the ability to study these regions using modern genomic and epigenomic tools. Recently, long-read sequencing and assembly methods have enabled reconstruction of complete centromeric and pericentromeric sequences, providing an unprecedented opportunity to study their organization, evolution, and function. In order to fully leverage these complete assemblies, we have created and applied new sequence analysis tools to reveal the organization and evolutionary relationships of human satellite DNA sequences. We also developed DiMeLo-seq, a long-read, single-molecule method for mapping protein-DNA interactions, and we applied it to measure the density of CENP-A containing nucleosomes across human centromeres. These efforts revealed strong associations between low CpG methylation, high CENP-A density, and the very recent expansion of underlying satellite repeats, raising important questions about the molecular and evolutionary mechanisms responsible for these associations.

Autumn 2022

9/28/22 - Dr. Cassandra Extavour | Harvard University
GSAIMS-invited speaker
sponsored jointly with UW Biology

10/5/22 - Dr. David Stern | Janelia

 

10/12/22 - Dr. Eszter Posfai | Princeton University

 

10/19/22 - Dr. Louis Kunkel | Harvard Medical School

 

10/26/22 - Dr. Andrew Ellington | University of Texas

 

11/2/22 - Dr. Sina Ghaemmaghami | University of Rochester

 

11/10/22 & 11/11/22 - Genome Sciences Symposium

11/16/22 - Dr. Melissa Gymrek | UC San Diego

 

11/30/22 - Dr. John Ray | Benaroya Research Institute

 

12/7/22 - Dr. Xin Chen | Johns Hopkins University

 

Winter 2023

1/4/23 -

1/11/23 - Dr. Ishmail Abdus-Saboor | Columbia University
GSAIMS-invited speaker

1/18/23 - reserved

1/25/23 - reserved

2/1/23 - reserved

2/8/23 - reserved

2/15/23 - Dr. Nancy Chen | University of Rochester
WiGS-invited speaker

2/22/23 -

3/1/23 - Dr. Sizun Jiang | Beth Israel Deaconess Medical Center

3/8/23 - Dr. Ian Ehrenreich | University of Southern California

 

Spring 2023

3/29/23 - Dr. Mona Singh | Princeton University

 

4/5/23 - Dr. Rachel Green | Johns Hopkins University

 

4/12/23 - Dr. Benjamin Wolfe | Tufts University

 

4/19/23 - Dr. Rupa Sridharan | University of Wisconsin

 

4/26/23 - Dr. Ophir Klein | UCSF

 

5/3/23 - Dr. Emilia Huerta-Sanchez | Brown University

5/10/23 -

5/17/23 -

5/24/23 -

5/31/23 - Dr. Christoph Bock | Center for Molecular Medicine, Austrian Academy of Sciences
lunch discussion hosted by Wei Yang