Dr. Thompson's research interest is in the development of methods for inference from genetic data, and particularly from data observed on large and complex pedigree structures. Questions of interest range from analyses of long-term gene frequency differentiation in widely dispersed populations, to short-term extinction of genes in the small population of a highly endangered species; from inference of genealogical relationships among individuals to inference of the genetic basis of traits from data observed on members of a known pedigree; and from analyses of patterns of genome sharing in plants to modern methods for human linkage analysis. In recent years, several of these questions have been addressed using Monte Carlo likelihood.
Anderson E.C., Williamson E.G., and Thompson E.A. (2000). Monte Carlo evaluation of the likelihood for Ne from temporally spaced samples. Genetics 156: 2109 - 2118.
Daw E.W., Thompson E.A., and Wijsman E.M. (2000). Bias in multipoint linkage analysis arising from map misspecification. Genetic Epidemiology 19: 366 - 380.
Graham J. and Thompson E.A. (2000). A coalescent model of ancestry for a rare allele. Genetics 156: 375-384.
Thompson E.A. (2000). MCMC estimation of multi-locus genome sharing and multipoint gene location scores. International Statistical Review 68: 53-73.