Marshall Horwitz

Research:

Dr. Marshall Horwitz is an internist and clinical medical geneticist whose research interests relate to genetic factors predisposing to hematopoietic malignancy and the clonal evolution of cancer. The major focus of his research centers on defining the genetic origins of cancers of the blood and using that as a paradigm for further understanding development. His laboratory employs genetic mapping and sequencing strategies to identify genes responsible for familial predisposition to leukemia, lymphoma, and bone marrow failure syndromes. In related work, Dr. Horwitz’s laboratory has developed a new approach for mapping cell fate during development by inferring the order in which mutations accumulate in somatic tissues. Dr. Horwitz directs the University of Washington School of Medicine Medical Scientist Training Program (MSTP) for concurrent M.D./Ph.D. students. He is the Cancer Genetics section editor of the Public Library of Science journal PLoS Genetics and former chair of the NIH Genetics of Health and Disease study section. Among his honors, Dr. Horwitz is a recipient of the Presidential Early Career Award for Scientists and Engineers as well as an NIH Director’s Pioneer Award

Selected Publications:

Horwitz, M.S., and Loeb, L.A. (1986) Promoters selected from random DNA sequences. Proc Natl Acad Sci U S A 83, 7405-7409. PMC386726.

Horwitz, M.S., and Loeb, L.A. (1988) An E. coli promoter that regulates transcription by DNA superhelix-induced cruciform extrusion. Science 241, 703-705.

Horwitz, M., Benson, K.F., Person, R.E., Aprikyan, A.G., and Dale, D.C. (1999) Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis. Nat Genet 23, 433-436.

Dale, D.C., Person, R.E., Bolyard, A.A., Aprikyan, A.G., Bos, C., Bonilla, M.A., Boxer, L.A., Kannourakis, G., Zeidler, C., Welte, K., Benson, K.F., and Horwitz, M. (2000) Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia. Blood 96, 2317-2322.

Benson, K.F., Li, F.Q., Person, R.E., Albani, D., Duan, Z., Wechsler, J., Meade-White, K., Williams, K., Acland, G.M., Niemeyer, G., Lothrop, C.D., and Horwitz, M. (2003) Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase. Nat Genet 35, 90-96

Person, R.E., Li, F.Q., Duan, Z., Benson, K.F., Wechsler, J., Papadaki, H.A., Eliopoulos, G., Kaufman, C., Bertolone, S.J., Nakamoto, B., Papayannopoulou, T., Grimes, H.L., and Horwitz, M. (2003) Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2. Nat Genet 34, 308-312. PMC2832179

Salipante, S.J., and Horwitz, M.S. (2006) Phylogenetic fate mapping. Proc Natl Acad Sci U S A 103, 5448-5453. PMC1414797

Salipante, S.J., Mealiffe, M.E., Wechsler, J., Krem, M.M., Liu, Y., Namkoong, S., Bhagat, G., Kirchhoff, T., Offit, K., Lynch, H., Wiernik, P.H., Roshal, M., McMaster, M.L., Tucker, M., Fromm, J.R., Goldin, L.R., and Horwitz, M.S. (2009) Mutations in a gene encoding a midbody kelch protein in familial and sporadic classical Hodgkin lymphoma lead to binucleated cells. Proc Natl Acad Sci U S A 106, 14920-14925. PMC2736436.

Carmichael, C.L., Wilkins, E.J., Chong, C.-E., Brautigan, P.J., Li, X.-C., Stankovic, M., Lin, M., Carmagnac, A., Butcher, C.M., Friend, K.L, Ekert, P.G., Kok, C.H., Brown, A.L., Lewis, I.D., To, L.B., Timms, A.E., Storek, J., Moore, S., Altree, M., Escher, R., Bardy, P.G., Suthers, G.K., D’Andrea, R.J., Horwitz, M.S., and Scott, H.S. Heritable (2011) GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia. Nat Genet 43, 1012-1017. PMC3184204.

Carlson, C.A., Kas, A., Kirkwood, R., Preston, B.D., Hayes, L.E., Salipante, S.J., and Horwitz, M.S. (2011) Decoding cell lineage from acquired mutations using arbitrary deep sequencing. Nat Methods 9, 78-80.

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