Brian Browning

Associate Professor of Medicine (Medical Genetics)
Adjunct Associate Professor of Genome Sciences

phone: (206) 685-8482
Health Sciences K-222
browning [ a t ] uw.edu
website

Research:

Dr. Browning's research is focused on the development of statistical and computational methods for analysis of large-scale genetic data from microarray genotyping and next-generation sequencing. These genetic data sets present computational and analytical challenges due to their size (which can exceed 40 billion data points), and due to the complex patterns of inter-marker correlation in the data. Carefully engineered algorithms and software are necessary to extract the full information from these rich data sets.

Selected Publications:

B L Browning, S R Browning (2011) A fast, powerful method for detecting identity by descent.  The American Journal of Human Genetics. 88(2):173-182.

S R Browning, B L Browning (2010) High resolution detection of identity by descent in unrelated individuals.  The American Journal of Human Genetics 86(4):526-539.

B L Browning Z Yu (2009) Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies.  The American Journal of Human Genetics 85(6):847-861.

B L Browning, S R Browning (2009) A unified approach to genotype imputation and haplotype phase inference for large data sets of trios and unrelated individuals.  The American Journal of Human Genetics.  84:210-223.

S R Browning, B L Browning (2007) Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering.  The American Journal of Human Genetics 81:1084-1097.  

B L Browning, S R Browning (2007) Efficient multilocus association testing for whole genome association studies using localized haplotype clustering.  Genetic Epidemiology 31(5):365-375.