We are interested in discovering new roles for RNA in human disease. We study all aspects of the RNA life cycle, from splicing to translation to degradation. Our broad goal is to uncover new biological phenomena that are relevant to the initiation, progression, or treatment of diseases such as leukemia and muscular dystrophy.

Selected Publications:

Dvinge H*, Kim E*, Abdel-Wahab O†, Bradley RK† (2016). RNA splicing factors as oncoproteins and tumour suppressors. Nature Reviews Cancer doi:10.1038/nrc.2016.51. *co-first authors; †co-senior authors

Lee SC*, Dvinge H*, Kim E, Cho H, Micol JB, Chung YR, Durham BH, Yoshimi A, Kim YJ, Thomas M, Lobry C, Chen CW, Pastore A, Taylor J, Wang X, Krivtsov A, Armstrong SA, Palacino J, Buonamici S, Smith PG, Bradley RK†, Abdel-Wahab O†(2016). Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins. Nature Medicine doi:10.1038/nm.4097. *co-first authors; †co-senior authors

See also: Splicing may be therapeutically targetable in acute myeloid leukemia.

Dvinge H, Bradley RK (2015). Widespread intron retention diversifies most cancer transcriptomes. Genome Medicine 7:45.

Kim E*, Ilagan JO*, Liang Y*, Daubner GM*, Lee SC-W, Ramakrishnan A, Li Y, Chung YR, Micol J-B, Murphy M, Cho H, Kim M-K, Zebari AS, Aumann S, Park CY, Buonamici S, Smith PG, Deeg HJ, Lobry C, Aifantis I, Modis Y, Allain FH-T, Halene S†, Bradley RK†, Abdel-Wahab O† (2015). SRSF2 mutations contribute to myelodysplasia by mutant-specific effects on exon recognition. Cancer Cell 27:617–630. *co-first authors; †co-senior authors

Feng Q, Snider L, Jagannathan S, Tawil R, van der Maarel SM, Tapscott SJ†, Bradley RK† (2015). A feedback loop between nonsense-mediated decay and the retrogene DUX4 in facioscapulohumeral muscular dystrophy. eLife 10.7554/eLife.04996. †co-senior authors

Ilagan JO*, Ramakrishnan A*, Hayes B, Murphy ME, Zebari AS, Bradley P, Bradley RK (2014). U2AF1 mutations alter splice site recognition in hematological malignancies. Genome Research doi:10.1101/gr.181016.114.
*co-first authors