In our group, we use next generation sequencing approaches to identify genes responsible for complex human conditions. Our primary areas of interest are inherited breast and ovarian cancer, the genetics of schizophrenia, and Mendelian disorders in founder populations. Our goals are to identify and characterize critical genes in informative families and populations. We are particularly interested in disentangling genetic heterogeneity in complex traits, thereby revealing the individually rare severe alleles that cause common disorders.  Our lab also applies genomic sequencing to the identification of victims of human rights abuses.

Selected Publications:

Casadei S*, Spurrell CH*, Mandell JB, Bernier CV, Lee MK, Thornton AM, Stray SM, Harrell MI, Gulsuner S, Press JZ, Pennington KP, Norquist BM, Swisher EM, Walsh T, King M-C. Mutations in 18 genes in breast cancer families with negative BRCA testing. In review.

Rippey CF, Walsh T, Gulsuner S, Brodsky M, Nord AS, Gasperini M, Pierce SB, Spurrell C, Coe BP, Krumm N, Lee MK, Sebat J, McClellan JM, King M-C. Formation of chimeric genes by copy number variation as a mutational mechanism in schizophrenia. Amer J Hum Genet. 93:697-710, 2013

Gulsuner S*, Walsh T*, Watts AC*, Lee MK, Thornton AM, Casadei S, Rippey CF, Shahin H, Consortium on the Genetics of Schizophrenia (COGS), PAARTNERS Study Group, Nimgaonkar VL, Go RCP, Savage RM, Swerdlow NR, Gur RE, Braff DL, King M-C, McClellan JM. Spatial and temporal mapping of de novo mutations in schizophrenia to a fetal prefrontal cortical network. Cell 154: 518-529, 2013

King M-C. ASHG 2012 Presidential Address: The scientist as a citizen of the world. Amer J Hum Genet 92: 319-322, 2013

Tobin DM, Roca FJ, Oh SF, McFarland R, Vickery TW, Ray JP, Ko DC, Zou Y, Bang ND, Chau TT, Vary JC, Hawn TR, Dunstan SJ, Farrar JJ, Thwaites GE, King MC, Serhan CN, Ramakrishnan L. Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell 148: 434-446, 2012

Roeb W, Higgins J, King MC. 2012 Response to DNA damage of CHEK2 missense mutations in familial breast cancer. Hum Mol Genet. 21:2738-2744, 2012

Walsh T, Casadei S, Lee MK, Pennil CC, Nord AS, Thornton AM, Roeb W, Agnew KJ, Stray SM, Wickramanayake A, Norquist B, Pennington KP, Garcia RL, King M-C, Swisher EM. 2011. Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing. Proc Natl Acad Sci USA. 108:18032-18037, 2011

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