Gail Jarvik
Professor of Medicine and Head, Division of Medical Genetics
Professor of Genome Sciences
Adjunct Professor of Epidemiology

Dr. Jarvik's major interest is in the genetics of common disease. She is involved in a number of research projects which address the inheritance of diseases of complex etiology. These are common diseases with multiple etiologic genes and environments. These projects use statistical genetics methods such as linkage analysis, complex segregation analysis, and association and interaction tests, in large data-sets collected in collaboration with molecular biologists and epidemiologists. She is particularly interested in the analysis of risk factors for coronary artery disease, including lipid disorders. A major focus of research is the study of gene-by-gene interactions in the inheritance of familial combined hyperlipidemia and elevated levels of apolipoprotein B. That study is also directed at mapping an apolipoprotein B elevating locus. A second major project involves lipid, oxidative, and inflammatory risk factors in a case-control study of carotid artery disease. This study also considers the predictors of carotid artery disease progression over time measured by magnetic resonance imaging. Finally, Dr. Jarvik another project evaluates the predictors of 1- and 4 year old neurological outcome in infants having open heart surgery in the first 6 months of life.

Publications:

Jarvik GP, Hatsukami TS, Carlson CS, Richter RJ, Jampsa R, Brophy VH, Margolin S, Rieder MJ, Nickerson DA, Schellenberg GD, Heagerty PJ, Furlong CE. Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular disease. Arterioscler Thromb Vasc Biol 23:1465 - 1471, 2003.

Gaynor JW, Gerdes M, Zackai EH, Bernbaum J, Wernovsky G, Clancy RR, Newman MF, Saunders AM, Heagerty PJ, D΄Agostino JA, McDonald-McGinn D, Nicolson SC, Spray TL, Jarvik GP. Apolipoprotein E genotype and neurodevelopmental sequelae of infant cardiac surgery. Journal of Thoracic and Cardiovascular Surgery, 126(6):1736-45, 2003.

Janer M, Fredrickson D, Stanford J, Badzioch M, Kolb S, Deutsch K, Peters MA, Goode EL, Welti R, DeFrance HB, Iwasaki L, Li S, Hood L, Ostrander E, Jarvik GP. A genomic scan of 254 families with hereditary prostate cancer. The Prostate 37:309-19, 2003.

Badzioch M, Igo RP, Gagnon F, Brunzell JD, Krauss RM, Motulsky AG, Wijsman EM, Jarvik GP. LDL particle size loci in familial combined hyperlipidemia: Evidence of multiple loci from a genome scan. Arterioscler Thromb Vasc Biol, 24:1942-50, 2004.

Rozek LS, Hatsukami TS, Richter RJ, Ranchalis J, Nakayama K, Gortner DA, Schellenberg GD, Furlong CE, Jarvik GP. The correlation of paraoxonase (PON1) activity with lipid and lipoprotein levels differs with vascular disease status. J. Lipid Research, 46:1888-95, 2005.