Samir Deeb

Research Professor of Genome Sciences and of Medicine

phone: (206) 543-4001
Health Sciences J-211A, Box 357720
sdeeb [ a t ] u.washington.edu

Research:

Dr. Deeb's research on color vision was initiated ten years ago in collaboration with Dr. Arno Motulsky in Medical Genetics and with Dr. Davida Teller's group in Psychology at the University of Washington. An important contribution of this group was the discovery that a single amino acid polymorphism in the red visual pigment was responsible for the variation in sensitivity to red light among individuals with normal color vision. The present studies are aimed at understanding differential expression of the red and green pigment genes in photoreceptors.

 Dr. Deeb's other major interest lies in the regulation of genes that are considered good candidates for insulin resistance and the associated dyslipidemia. The genes encoding lipoprotein lipase, hepatic lipase and muscle hexokinase are now being investigated.  Studies have recently focused on the role of common hepatic lipase promoter variants in determining plasma hepatic lipase activity and the phospholipid content of high-density and low-density lipoproteins.

Selected Publications:

Deeb, S.S. and Peng, R. (2000) The C-514T polymorphism in the human hepatic lipase gene promoter diminishes its activity. J. Lipid Res. 41:155-158.

Deeb, S.S., Diller, L.C., Williams, D.R., Dacey, D.M. (2000) Interindividual and topographical variation of L:M ratios in monkey retinae. J. Optical Soc. Amer. Image Sci Vis. 17:538-544.

Hayashi, T., Huang, J., Deeb, S.S. (2000) RINX, a novel homeobox gene expressed in the inner nuclear layer of the adult retina. Genomics 67:128-139.

Zambon, A, Deeb, S.S., Brown, B.G., Hakanson, J.E., Brunzell, J.D. (2001) Common hepatic lipase gene promoter variant determines clinical response to intensive lipid-lowering treatment. Circulation 103:792-798.

Brunzell, J.D and Deeb, S. (2001) Lipoprotein Lipase, apolipoprotein CII and Hepatic Lipase Deficiencies In: The Molecular and Metabolic Bases of Inherited Disease, Eighth Edition. C. R. Scriver, A. L. Beaudet, W.S. Sly, and D. Valle. Ed. Vol II, PP 2789-2816.

Motulsky, A.G. and Deeb, S. (2001) Color Vision and its Genetic Defects. In: The Molecular and Metabolic Bases of Inherited Disease, Eighth Edition. C. R. Scriver, A. L. Beaudet, W.S. Sly, and D. Valle. Vol. IV, Ed. PP 5955-5976.

additional publication listings available via PubMed