Dr. Wijsman's research is directed towards the development and application of quantitative methods for analysis of human genetic data, including statistical techniques of gene mapping, modelling modes of inheritance, and identifying regions of identify-by-descent through linkage disequilibrium analysis.

Selected Publications:

Gagnon F, Jarvik GP, Badzioch MD, Motulsky AG, Brunzell JD, Wijsman EM (2005) Genome scan for quantitative trait loci influencing HDL levels: evidence for multilocus inheritance in familial combined hyperlipidemia. Human Genetics 117:494-505.

Raskind WH, Igo R, Chapman N, Berninger VW, Matsushita M, Brkanac Z, Holzman T, Brown M, Thomson J, Wijsman EM (2005) A genome scan in multigenerational families with dyslexia: Identification of a novel locus on chromosome 2q that contributes to phonological decoding efficiency. Mol Psych 10:699-711.

Wijsman EM, Daw EW, Yu C-E, Payami H, Steinbart EJ, Nochlin D, Conlon EM, Bird TD, Schellenberg GD. Evidence for a Novel Late-onset Alzheimer’s Disease Locus on Chromosome 19p13.2. Am J Hum Genet 75:398-409.

Yu C-E, Dawson G, Munson J, D'Souza I, Osterling J, Estes A, Leutenegger A-L, Flodman P, Smith M, Raskind WH, Spence MA, McMahon W, Wijsman EM, Schellenberg GD (2002) Presence of large deletions in kindreds with autism. The American Journal of Human Genetics, 71:100-115.

Goddard KAB, Wijsman EM (2002) Characteristics of genetic markers and maps for cost-effective genome screens using diallelic markers. Genetic Epidemiology 22:205-220.

Daw EW, Payami H, Nemens EJ, Nochlin D, Bird TD, Schellenberg GD, Wijsman EM (2000) The number of trait loci in late-onset Alzheimer's disease. The American Journal of Human Genetics 66:196-204.

Chapman NH, Wijsman EM (1998) Genome screens using linkage disequilibrium tests: optimal marker characteristics and feasibility. American Journal of Human Genetics 63:1872-1885.

Levy-Lahad E, Wijsman EM, Nemens E, Anderson L, Goddard KAB, Weber, JL, Bird TD, Schellenberg GD (1995) A familial Alzheimer's disease locus on chromosome 1. Science 269:970-973.

Schellenberg GD, Bird TD, Wijsman EM, Orr HT, Anderson L, Nemens E, White JA, Bonnycastle L, Weber JL, Alonso ME, Potter H, Heston LL, Martin GM (1992) Genetic linkage evidence for a familial Alzheimer disease locus on chromosome 14. Science 258:668-671.

Wijsman EM (1987) A deductive method of haplotype analysis in pedigrees. American Journal of Human Genetics 41:356-373.

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