My current research interests are all related to the application of genetic concepts and methodologies to the elucidation of the pathobiology of aging in humans and other mammals. There are two broad areas of interest: 1) Genetic and epigenetic regulation of stochastic variations in gene expression within homologous somatic cells, their expanding age-related drifts, and their relationship to the quasi-stochastic distributions of a wide range of geriatric pathologies. 2) The discovery of novel genetic loci mutations at which result in segmental progeroid syndromes that are operationally referred to as Atypical Werner Syndrome. These studies are expedited by the establishment of an International Registry of Werner syndrome in our laboratory.
Kaeberlein M, Rabinovitch PS, Martin GM. Healthy aging: The ultimate preventative medicine. Science. 2015 Dec 4;350(6265):1191-3.
Lessel D et al. POLD1 Germline Mutations in Patients Initially Diagnosed with Werner Syndrome. Hum Mutat. 2015 Nov;36(11):1070-9.
Lessel D et al. Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features. Nat Genet. 2014 Nov;46(11):1239-44.
Saha B, Cypro A, Martin GM, Oshima J. Rapamycin decreases DNA damage accumulation and enhances cell growth of WRN-deficient human fibroblasts. Aging Cell. 2014 Jun;13(3):573-5.
Martin GM. The biology of aging: 1985-2010 and beyond. FASEB J. 2011 Nov;25(11):3756-62.
Martin GM. Stochastic modulations of the pace and patterns of ageing: impacts on quasi-stochastic distributions of multiple geriatric pathologies. Mech Ageing Dev. 2012 Apr;133(4):107-11.