UW Genome Sciences

Research:

Our lab seeks to understand how genotype specifies phenotype by developing new technologies. We answer questions like how does a protein’s sequence encode its fold and function? How do changes in a person's genome sequence influence disease risk, prognosis and treatment? How do gene expression patterns combine with protein activity to define cellular processes like growth, migration and communication?

We are global leaders in high-throughput, sequencing-based assays; we have deep expertise in large-scale experimental approaches and computational analyses. We have led the use of functional genomics data to interpret the clinical consequences of human genetic variation. And, by illuminating the effects of genetic variation at unprecedented scale, we have impacted diverse fields including protein design and engineering, protein structure determination, protein allostery and regulation, molecular and viral evolution, drug resistance, computational variant effect prediction, and the analysis of human genetic variants.

Selected Publications:

please see PubMed