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The Manoil group studies the virulence and antibiotic susceptibility of several bacterial pathogens: Pseudomonas aeruginosa, Francisellatularensis and Burkholderia pseudomallei. P. aeruginosa causes a variety of opportunistic infections in humans, including chronic lung infections in individuals with cystic fibrosis. F. tularensis and B. pseudomallei are important biothreat agents, and are the causative agents of tularemia and melioidosis, respectively.

The laboratory employs functional genomic approaches to study the bacterial pathogens. The lab has created (with the University of Washington Genome Center) comprehensive sequence-defined transposon libraries of the bacteria, and is in the process of carrying out large-scale studies to identify and characterize genes required for virulence and antibiotic susceptibility.

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