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The Manoil group studies the virulence and antibiotic resistance traits of several bacterial pathogens: Pseudomonas aeruginosaAcinetobacter baumannii, Burkholderia pseudomallei and Klebsiella pneumoniae. These pathogens cause a variety of infections in humans, which are challenging to treat because of intrinsic antibiotic resistance of the bacteria .

The laboratory employs genome-scale genetic approaches to study the bacteria. The lab has created ordered, sequence-defined transposon libraries for all of the species, and has carried out large-scale studies to identify and characterize genes required for their virulence and antibiotic resistance.

 

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