Molecular Data on Chloroquine and Antifols Worldwide


South America
CloneOrigin [Ref]SensitivityAmino Acid Residue
SDXDAPSONEDHPS
S436A437K/L540A581A613
PDAPBrazil[1]RSGEGA
AP1Brazil[1]RSGEGA
PV1Brazil[1]RSGEGA
PV2Brazil[1]RAGEGA
IQBrazil[3]RSGEGA
BA1Bolivia[30]RSGEGA
HB3Honduras[31]SSAKAA
Middle East
CloneOrigin [Ref]SensitivityAmino Acid Residue
SDXDAPSONEDHPS
S436A437K/L540A581A613
Y17,19Yemen[2]SSAKAA
O15Oman[2]SSAKAA
A7Afghanistan[2]SSAKAA
PK2-11Pakistan[2]SSAKAA
Africa
CloneOrigin [Ref]SensitivityAmino Acid Residue
SDXDAPDHPS
S436A437K/L540A581A613
S2-10Mali[2]RSGKGA
B2,6Mali[2].SGKGA
B1Mali[2].SA/GKA/GA
B3Mali[2].AA/GKA/GA
B4Mali[2].SGKAA
B5,7Mali[2].S/AA/GKAA
B8Mali[2].S/AGKAA
ML1Mali[30]RFAKAS/T
ML2Mali[30]RSAEAA
KEN1Kenya[2]RAAKAA
KEN2Kenya[2]RSGEAA
KEN4Kenya[2].SAKAA
P4Kenya[2].SGKGA
KEN5Kenya[30]RSA/GEGA
TAN1Tanzania[2]SSAKAA
TAN2Tanzania[2]RSAKAA
TAN3Tanzania[2]RSGKGA
TAN10Tanzania[2].SGEA/GA
TAN17Tanzania[2].AAKAA
NM4Kenya[8].SAKAA
NM1Kenya[8].S/AAKAA
NM2Kenya[8].AAKAA
NM3Kenya[8].SA/GEAA
NM4Kenya[8].SGEAA
NM5Kenya[8].AGKAA
M24Kenya[31].SAKAA
FCR3Gambia[31].SAKAA
3D7Africa[31].SAKAA
MI1Malawi[30]RAGKAA
MI2Malawi[30]RSA/GEAA
South-East Asia
CloneOrigin [Ref]SensitivityAmino Acid Residue
SDXDAPDHPS
S436A437K/L540A581A613
K8Vietnam[2].S/AGKA/GA
K5Vietnam[2].SGKGA
K9Vietnam[2].SA/GKA/GA
K16Vietnam[2].AGKA/GA
K11,13Vietnam[2].S/AGKA/GA
P1Vietnam[2].SGKGA
DR1Papua New G. [7].SGKAS
DR2-24Papua New G. [7].SAKAA
K1Thailand[31].SGKGA
Dd2Indochina[31].FGKAS


Chloroquine Response alleles
PFCRT
South America
CloneOrigin [Ref]SensitivityAmino Acid Residues
7274757697220271326356371
HB3Honduras [x]SCMNKHAQNIR
7G8Brazil [X]RSMNTHSQDLR
DIV30Brazil [X]RSMNTHSQDLR
ICSN66Brazil [X]RSMNTHSQDLR
ECPBrazil [X]RSMNTHSQDLR
PADBrazil [X]RSMNTHSQDLR
ItD2Brazil [X]RSMNTHSQDLR
Ecu1110Ecuador [X]RCMNTHSQDLR
JavColumbia [X]RCMETQSQNIT
IAJColombia [X]RCMETQSQNIT
Chloroquine Response alleles
PFCRT
South-East Asia
CloneOrigin [Ref]SensitivityAmino Acid Residues
7274757697220271326356371
D10PNG [X]SCMNKHAQNIR
T2/C6Thailand [X]SCMNKHAQNIR
CampMalaysia [X]SCMNKHAQNIR
Dd2Indochina [X]RCIETHSESTI
VI/SVietnam [X]RCIETHSESTI
TM284Thailand [X]RCIETHSESTI
ItG2F6SE Asia [X]RCIETHSESII
FCBSE Asia [X]RCIETHSESII
R29SE Asia [X]RCIETHSESII
Jc1Cambodia [X]RCIETHSESTI
Chloroquine Response alleles
PFCRT
Africa
CloneOrigin [Ref]SensitivityAmino Acid Residues
7274757697220271326356371
105/7Sudan [X]SCMNKHAQNIR
106/1Sudan [X]SCIEKHSESII
RENSudan [X]SCMNKHAQNIR
FAB9South Africa SCMNKHAQNIR
K39Kenya [X]SCMNKHAQNIR
M24Kenya [X]SCMNKHAQNIR
LF4/1Liberia [X]SCMNKHAQNIR
SL/D6S. Leone [X]SCMNKHAQNIR
BC5Mali [X]SCMNKHAQNIR
M5Mali [X]SCMNKHAQNIR
102/1Sudan [X]RCIETHSESTI
RB8South Africa [X]RCIETHSESII
PARUganda [X]RCIETHSESII
KMWIIKenya [X]RCIETHSESII
M2Mali [X]RCIETHSESII
S35CQMali [X]RCIETHSESII
CAISao Tome [X]RCIETHSESII
Chloroquine Response alleles
PFCRT
Europe
CloneOrigin [Ref]SensitivityAmino Acid Residues
7274757697220271326356371
NF54Netherlands [X]SCMNKHAQNIR
General
Pf mdr1
CloneOrigin [Ref]SensitivityAmino Acid Residue
N86*
17Laos [X]RY
18Laos [X]SY
20Mali [X]RY
South America
CloneOrigin [Ref]SensitivityAmino Acid Residue
CYCPYRDHFR
A16C50N51C59S108V140I164BOLIVIA R.
It.G2.F6Brazil [5].S.A-NCT--
It.D12Brazil [5].RA-ICN--.
7G8Brazil [5].RA-ICN--.
HB3Honduras [5].RA-NCN--.
PDAPBrazil [1].R-RICN-I.
AP1Brazil [1].R-RICN-I.
AP2Brazil [1].R-RICN-L.
PV1Brazil [1].R-RICN/T-I.
PV2Brazil [1].R-CICN-I.
PV3Brazil [1].R-RNCN/T-I.
PV4Brazil [1].R-CNCN-I.
PV5Brazil [1].R-CNCN/T-I.
PV6Brazil [1].R-RICN-I.
IT1Peru [3].R-I--N-L.
IT2Peru [3].R----N-L.
IT3Peru [3].S----N--.
St. LuciaEl Salvador [18].R-------.
FCBColombia [10]RSARIRN-L*GKKNE
BOL1Bolivia [18]RRARIRN-LGKKNE
South-East Asia
CloneOrigin [Ref]SensitivityAmino Acid Residue
CYCPYRDHFR
A16C50N51C59S108V140I164
Dd2Indochina [5].RA-ICN--
CampMalaysia [5].RA-NCN--
HOAVietnam [4,6]SRA-IRNVI
NT1Vietnam [4,6]SRA-IRNVI
F25Vietnam [4,6]SRA-IRNVI
VI/SVietnam [4,6]RRA-IRNVL
VP35Vietnam [4,6]RRA-IRNVL
W282Vietnam [10]IRA-IRNVI
T9/96Thailand [4,6]SSA-NCSVI
T9/94Thailand [4,6]RSV-NCTLI
K8Vietnam [2]SSA-NCS-I
VP1-6, 11, 14-16Vietnam [4]SRA-IRNVI
VP18-20, 22-29, 31-34, 37, 41, 44, 46, 47Vietnam [4]SRA-IRNVI
VP7, 9, 10, 12Vietnam [4,6]SRA-NRNVI
VP13, 17, 21, 30, 36, 38-40, 42, 43, 45Vietnam [4,6]SRA-NRNVI
VP8Vietnam [4,6]RSV-NCTLI
V-1Vietnam [9].R---RN--
TuanLaos [6]SRA-NCN-I
LD1Vietnam [6]SRA-NCN-I
PKVietnam [6]SRA-NCN-I
K5Vietnam [2].RA-NRN-I
K1,3,12,14Vietnam [2].RA-IRN-I
K4,6,17-19Vietnam [2].RA-IRN-I
K9Vietnam [2].RA-IRN-I
K15Vietnam [2].RA-IRN-I
K16Vietnam [2]RRA-IRN-I
K7Vietnam [2].RA-IRN-L
K2Vietnam [2]SRA-N/IC/RN-I
K10Vietnam [2]SSA-N/IC/RS/N-I
K11,13Vietnam [2].RA-IC/RN-I
K20Vietnam [2]SSA-N/IC/RS/N-I
Palo-altoVietnam [9].R(I)----T--
P1, 2B, 3AVietnam [2].RA-NRN-I
P4A, 4B, 5A, 6A, 7B, 8, 10, 14, 17Vietnam [2]SRA-IRN-I
P3B, 7A, 9, 12Vietnam [2]RRA-NRN-L
P2A, 5B, 16Vietnam [2]RRA-IRN-L
K-1Thailand [9].R---RN--
Csl-2Thailand [9].R---RN-L
DR1, 3, 6, 7, 9, 11, 12, 13, 15, 16, 17, 22, 23Papua New Guinea [7]SSA-NCS-I
DR2Papua N. Guinea [7]RRA-NRN-I
DR4Papua N. Guinea [7]RIA-NRN-I
DR5Papua N. Guinea [7]IIA-NCT-I
DR8Papua N. Guinea [7]RRA-NCN-I
DR10Papua N. Guinea [7]RRA-NRN-I
DR14, 20Papua N. Guinea [7]RRA-NRN-I
DR18Papua N. Guinea [7]RRA-NCN-I
DR19Papua N. Guinea [7]IR--NRN-I
DR21Papua N. Guinea [7]IRA-NRN-I
DR24Papua N. Guinea [7]RRA-NRN-I
Africa
CloneOrigin [Ref]SensitivityAmino Acid Residue
CYCPYRDHFR
A16C50N51C59S108V140I164
SL/D6Sierra Leone [5]S.A-NCS--
L.E5Liberia [5]S.A-NCS--
FCR3Gambia [5]RSV-NCT--
NM1Kenya [8]S.--NCN-I
NM2Kenya [8]S.--ICN-I
NM3Kenya [8]S.--NRN-I
NM4Kenya [8]S.--IRN-I
NM5Kenya [8]R.--IRN-I
NM6Kenya [8]R.A-ICN-I
47/PF042Kenya [8]RSA-NCS-I
M24Kenya [8].SA-NCS--
K39Kenya [19].SA-NCS--
K1Kenya [2].RA.IRN-I
K3Kenya [2].RA-IRN-I
K4Kenya [2].RA-NRN-I
K7Kenya [2].RA-NCN-I
K8,9Kenya [2].RA-IRN-I
K11Kenya [2].RA-ICN-I
C1,2,5,6Kenya [2].SA-NCS-I
C3Kenya [2].SA-NC/RS/N-I
C4Kenya [2].SA-NRN-I
KEN1Kenya [30]R.A-IRN-I
Palo-altoUganda [9].R(I)----T-I
UG1Uganda [20].R--IRS--
UG2Uganda [20].S--NCN--
UG3Uganda [20].R--1RN--
UG4Uganda [20].R--NRN--
UG5Uganda [20].R--ICN--
GN1Gabon [21].R--IRN--
GN2Gabon [21].R--ICS--
GN3Gabon [21].R--NRS--
GN4Gabon [21].R--NCN--
NF7Ghana [11].S--NCS--
FCBAfrica [19].R--NCN/T--
AF248503Cameroon [12].SA-NCS-I
AF248506Cameroon [12].SA-NCN-I
AF248507Cameroon [12].SA-NRN-I
AF248510Cameroon [12].SA-IRN-I
AF248527Cameroon [12].RA-IRN-I
AF248530Cameroon [12].RA-N/IC/RS/N-I
CICameroon [13,14].RA-N/IC/RS/N-I
TITanzania [15].RA-ICN--
TN2Tanzania [16].SA-IRS--
TN3Tanzania [16].RA-NRN--
TN4Tanzania [16].RA-ICN--
TN1Tanzania [2]SSA-NCS-I
TN2Tanzania [2].RA-NCS-I
TN11Tanzania [2].RA-NCS-I
TN16Tanzania [2].RA-IRN-I
TN19Tanzania [2].RA-NC/RN-I
S2-10Mali [2]SSA-NCS-I
S11Mali [2].RA-IRN-I
B2,6Mali [2]SSA-NCS-I
B1Mali [2]SSA-NCS-I
B3Mali [2]SSA-NCS-I
B5,7Mali [2]SSA-NCS-I
B4Mali [2].RA-IRN-I
ML1Mali [17].RA-IRN--
ML2Mali [17].S--IRN--
ML3Mali [17].R--ICN--
ML4Mali [17].R--NRN--
ML5Mali [17]R.--IRN--
MI1Malawi [18]R.A-IRN.I
Middle East
CloneOrigin [Ref]SensitivityAmino Acid Residue
CYCPYRDHFR
A16C50N51C59S108V140I164
Y17,19Yemen [2]SSA-NCS-I
O15Oman [2].RA-NCN-I
O1Oman [2].RA-NRN-I
A7Afghanistan [2].RA-ICN-I
A12Afghanistan [2].RA-NRN-I
PK2-6, 8-11Pakistan [2].RA-NRN-I
PK20Pakistan [2]SSS-NRS-I
Europe
CloneOrigin [Ref]SensitivityAmino Acid Residue
CYCPYRDHFR
A16C50N51C59S108V140I164
3D7The Netherlands [5].SACNCSVI
NF36The Netherlands [5].S-......
Laboratory Generated
CloneOrigin [Ref]SensitivityAmino Acid Residue
CYCPYRDHFR
SB1Seattle [22].RN51S108NN188T.
SB2Seattle [22].R..N188TS209P
SB3Seattle [22].R.S108NN188T.
SB4Seattle [22].RN51IS108N.V213E
SB5Seattle [22].RN51IS108N.V213G
SB6Seattle [22].RN51IS108NF196L.
SB7Seattle [22].RN51IS108NS189R.
SB8Seattle [22].RN51IS108N.V213A

References

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