UW Genome Sciences

Dr. Stamatoyannopoulos' research work spans a variety of areas of human genetics and genetic hematology including population genetics, impact of genetic counseling, the structure and function of hemoglobinopathies, the genetics of thalassemia syndromes and the analysis of the molecular and cellular control of globin gene switching. In the last twenty years his research has focused on the development of gene therapy for hemoglobinopathies and other disorders that can be cured by gene transfer into stem cells.

His interest in population genetics include the genetics of the Bronze Age population of the Minoans and the Myceneans and the genetics of the populations of Greece and the Balkan peninsula.

Selected Publications:

Liu, M., Maurano, M., Wang, H., Qi, H., Song, C.-Z., Navas, P., Emery, D., Stamatoyannopoulos, J.A. & Stamatoyannopoulos, G.: Genomic discovery of potent chromatin insulators for human gene therapy. Nature Biotechnology 33:198-203, 2015.

Paschou, P., Drineas, P., Yannaki, E., Razou, A., Kanaki, K., Tsetsos, F., Padmanabhuni, S.S., Michalodimitrakis, M., Rendae, M.C., Pavlovic, S., Anagnostopoulos, A., Stamatoyannopoulos, J.A., Kidd, K.K., Stamatoyannopoulos, G.: Maritime route of colonization of Europe. PNAS 111: 9211-9216, 2014.

Yannaki E, Karponi G, Zervou F, Constantinou V, Bouinta A, Tachynopoulou V, Kotta K, Jonlin E, Papayannopoulou T, Anagnostopoulos A, Stamatoyannopoulos G.  Hematopoietic stem cell mobilization for gene therapy: superior mobilization by the combination of granulocyte-colony stimulating factor plus plerixafor in patients with β-thalassemia major.  Hum Gene Ther. 24:852-860, 2013.

Hughey JR, Paschou P, Drineas P, Mastropaolo D, Lotakis DM, Navas PA, Michalodimitrakis M, Stamatoyannopoulos JA, Stamatoyannopoulos G. A European Population in Minoan Bronze Age Crete. Nat Commun. 4:1861, 2013.

Higgs, D, Engel, J, Stamatoyannopoulos, G: Thalassaemia, Lancet. 379:373-83, 2012.