Spoke Assay Inhibition Values

Drugs Y5D3 Pf (D6) Pf (Mik) Human BCp HCp Tg Pc
PT Series DHFR DHFR DHFR DHFR DHFR-TS DHFR-TS DHFR DHFR
182 - 3.07 1.23 0.67 0.63 - - -
183 - 3.23 1.37 0.70 0.67 0.63 0.67 -
186 - 2.33 0.93 - - - - -
187 - 3.15 1.40 0.85 1.10 0.80 - -
196 - 3.25 1.00 - - - - -
228 - 2.15 0.85 - - - - -
235 - 1.75 - - - - - -
262 - 2.30 0.85 - 0.65 0.65 0.65 -
263 - 1.65 - - 0.65 0.65 - -
264 - 2.70 0.95 1.20 1.10 0.70 - 1.10
265 - 2.25 - - - - - -
266 - 1.60 - - 0.70 - - -
267 - 1.30 - - - - - -
268 - 1.70 - - - - - -
269 - 0.70 - - - - - -
271 - 2.10 - - - - - -
301 - 2.20 - - 0.75 0.65 - -
304 - 1.00 - - - - - -
310 - 1.00 - - - - - -
312 - 1.45 - - - - - -
313 - 1.50 - - - - - -
315 - 0.65 - - - - - -
323 - 1.95 0.80 - - - 0.75 -
328 - 1.65 - 0.65 0.65 - - -
331 - 3.00 - - - - - -
333 - 0.85 - - - - - -
653 - 1.50 - - - - - -
658 - 1.83 - - - - - -
659 - 2.70 1.10 - 0.67 0.67 - 0.63
660 - 3.10 1.40 0.63 0.70 0.67 - -
661 - 3.43 1.70 - 0.70 0.70 0.63 0.87
PY Series                
838 - 3.27 1.90 1.97 1.90 1.87 2.03 0.67
839 - 3.10 1.93 1.70 0.90 1.17 2.03 -
840 - 2.43 0.63 - 0.63 0.63 - -
846 - 2.93 2.67 0.70 0.77 0.63 1.50 0.77
847 - 2.53 0.70 - - - - -
848 - 2.13 0.63 - - - - -
850 0.63 2.77 2.47 2.10 1.90 1.73 2.40 1.37
851 - 2.90 2.57 2.40 1.90 1.73 2.47 1.37
855 - 2.30 0.70 - - - 0.73 -
856 0.87 3.27 3.10 2.50 2.73 2.87 2.70 2.13
857 - 2.07 0.83 - - - 0.70 -
858 - 3.23 1.87 1.27 - - 0.70 -
859 - 3.37 2.90 2.40 2.53 2.43 2.63 1.50
861 0.63 2.07 1.00 0.70 0.80 0.83 0.87 0.67
862 - 2.87 1.30 1.23 0.80 0.80 1.03 -
865 - 1.43 0.70 0.63 0.67 0.63 0.67 -
866 - 2.00 - - - 0.63 0.63 -
867 - 1.77 0.67 - 0.63 0.63 0.67 -
868 - 3.20 2.60 1.63 0.73 0.73 1.40 0.73
869 - 0.80 - - - - - -
870 - 1.50 - - - - - -
871 - 3.17 2.33 1.10 0.97 0.93 1.10 0.67
873 - 3.47 2.00 1.30 1.13 0.90 1.23 -
874 - 3.43 2.90 2.53 2.10 2.10 2.13 1.20
876 1.33 3.83 3.50 2.93 2.33 2.10 2.33 1.87
877 1.60 3.73 3.47 2.67 2.73 2.53 2.53 2.00
878 1.27 3.53 2.93 2.40 2.30 2.07 2.00 1.67
879 - 2.40 0.83 - 0.67 0.70 0.77 -
880 - 2.53 1.13 - 1.03 0.80 1.07 0.63
883 0.63 2.13 0.63 - 0.63 0.63 0.63 -
884 - 3.20 2.23 0.90 0.73 0.70 0.93 0.70
887 - 1.97 - - - - - -
889 - 2.47 0.63 - 0.63 - - -
895 - 2.57 0.63 - 0.63 0.63 - -
897 1.00 3.77 3.37 2.47 2.50 2.17 2.37 1.60
900 1.63 3.83 3.77 3.13 3.20 2.80 3.27 2.63
901 0.93 3.47 3.30 2.30 2.23 1.97 2.53 1.67
902 - 2.50 - - - - - -
903 - 3.60 3.43 2.27 0.93 0.73 1.80 1.30
905 1.43 3.90 3.80 3.57 3.43 3.37 3.37 2.87
907 - 3.37 2.90 2.10 2.27 2.30 2.33 1.33
908 1.30 3.80 3.87 3.23 3.07 2.73 3.13 2.27
909 1.10 3.70 3.73 2.87 2.90 2.57 2.97 1.93
910 0.93 3.80 3.77 3.07 3.10 2.87 3.03 1.80
911 1.07 3.37 2.73 1.97 2.17 2.10 2.17 1.47
912 - 2.77 1.17 - 0.67 0.63 0.67 -
913 - 3.13 0.77 - - - 0.63 -
915 1.27 3.73 3.57 3.10 2.70 2.53 3.13 2.50
916 0.80 3.87 3.53 2.47 2.20 2.03 2.47 1.53
917 0.97 3.73 3.57 2.77 2.57 2.47 2.97 2.27
918 - 3.37 2.83 1.07 1.03 0.73 1.93 -
919 1.37 3.40 3.07 2.03 2.00 1.83 2.30 1.83
920 1.07 3.73 3.63 2.77 2.77 2.60 2.80 2.20
922 - 2.40 1.47 0.63 - - 0.73 0.80

This chart displays the inhibition values for each test compound against the various yeast strains. All values were obtained by measuring from the center of each plate to the point of yeast growth. Measurements were done in centimeters and a "-" represents a failure by that compound to inhibit the yeast (<.6cm)


Last Updated on 9/19/2000
By Genetics Office