Dr. Stamatoyannopoulos' laboratory focuses on how the human genome encodes transcriptional regulatory programs that unfold during development and differentiation, and how defects in these programs underlie common diseases.  

Research areas:

Ongoing efforts in the Stamatoyannopoulos lab:


Selected Publications:

The accessible chromatin landscape of the human genome.  Nature 489:75-82, 2012.

Systematic localization of common disease-associated variation in regulatory DNA. Science  337:1190-5, 2012.

Circuitry and dynaomics of human transcription factor regulatory networks.  Cell 150:1274-86, 2012.

Developmental fate and cellular maturity encoded in human regulatory DNA landscapes.  Cell 154:888-903, 2013.

Conservation of trans-acting circuitry during mammalian regulatory evolution. Nature 489:83-90, 2012.

Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution.  Science 346:1007-12, 2014.

Exonic transcription factor binding directs codon choice and impacts protein evolution.  Science 342:1367-72, 2013.

An expansive human cis-regulatory lexicon encoded in transcription factor footprints.  Nature 489:83-90, 2012.

Coupling transcription factor occupancy to nucleosome architecture with DNase-FLASH.  Nature Methods, 11:66-72, 2013.