George Stamatoyannopoulos
Professor of Genome Sciences and of Medicine
Adjunct Professor of Pathology

Dr. Stamatoyannopoulos' research work spans a variety of areas of human genetics and genetic hematology including population genetics, impact of genetic counseling, the structure and function of hemoglobinopathies, and the genetics of thalassemia syndromes. In the last twenty years his research has focused on the analysis of the molecular and cellular control of globin gene switching. Another area of concentration is the development of gene therapy for hemoglobinopathies and other disorders that can be cured by gene transfer into stem cells.

Publications:

McArthur, M., Gerum, S. and Stamatoyannopoulos, G.: Quantification of DNaseI-sensitivity by real-time PCR: Quantitative analysis of DNaseI-hypersensitivity of the mouse b-globin LCR. J. Mol. Biol 313:27-34, 2001.

Shayakhmetov, D.M., Carlson, C.A., Stecher, H., Li, Qiliang, Stamatoyannopoulos, G., and Lieber, A.: A high-capacity, capsid-modified hybrid adeno-AAV vector for stable transduction of human hematopoietic cells. J. Virol. 76:1135-1143.

Song, C.-Z., Asano, H., and Stamatoyannopoulos, G.: Functional interaction between coactivators CBP/p300, P/CAF and transcription factor FKLF-2. J. Biol. Chem. 277:7029-7036, 2002.

Duan, Z.-J., Fang, X., Hu, Z., Rohde, A., Han, H., Stamatoyannopoulos, G., and Li, Q.: Developmental specificity of recruitment of TBP to the TATA box. Proc. Natl. Acad. Sci. U.S.A. 99:5509-5514, 2002.

Emery, D.W., Yannaki, E., Tubb, J., Nishino, T., Li, Q., and Stamatoyannopoulos, G.: Development of virus vectors for gene therapy of b chain hemoglobinopathies: flanking with a chromatin insulator reduces g-globin gene silencing in vivo. Blood 100:2012-2019, 2002.

Li, Q., Zhang, M., Han, H., Rohde, A., and Stamatoyannopoulos, G.: Evidence that Dnase I hypersensitive site 5 of human beta-globin LCR functions as a chromosomal insulator in transgenic mice. Nucl. Acids Res. 30:2484-2491, 2002.

Li, Q., Peterson, K.R., Fang, X., and Stamatoyannopoulos, G.: Locus control regions. Blood 100:3077-3086, 2002.

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