Zhaoshi Jiang

Joined Program: 2004
Previous Degree: B.S. Clinical Medicine, Zhejiang University
Eichler Lab
zhaoshi (at) u.washington.edu

Research:
Highly duplicated regions of human genome are hotspots for gene innovation, structural polymorphism and genomic diseases. However, the evolutionary origin and underlying biological mechanism of human segmental duplications are not well understood due to the complexity of sequence organization of these regions. Working with our collaborators (Pavel Pevzner and Haixu Tang), I am currently using a modified A-Brujin algorithm and sequence divergence analysis to define the ancestral loci (duplicons) of segmental duplications. Based on the information of ancestral loci, I also try to reconstruct the detailed evolutionary history and provide insight into the underlying biological mechanism of segmental duplications by evaluating both neutral and selectionist models for their origin.

Publications:

1. Yohn CT*, Jiang Z*, McGrath SD,Hayden KE, Khaitovich P, Johnson ME, Eichler MY, McPherson JD, Zhao S, Pääbo S, Eichler EE.(2005) Lineage-Specific Expansions of Retroviral Insertions within the Genomes of African Great Apes but Not Humans and Orangutans.PLoS Biol 2005;3(4): e110. * Equal first author
   
   
2. Locke DP, Jiang Z, Pertz LM, Misceo D, Archidiacono N, Eichler EE.(2005)Molecular evolution of the human chromosome 15 pericentromeric region.Cytogenet Genome Res. 2005;108(1-3):73-82.
   
   
3. She X, Jiang Z, Clark RA, Liu G, Cheng Z, Tuzun E, Church DM, Sutton G, Halpern AL, Eichler EE(2004)Shotgun sequence assembly and recent segmental duplications within the human genome Nature.2004 Oct 21;431(7011):927-930.
   
   
4. She X, Horvath JE, Jiang Z, Liu G, Furey TS, Christ L, Clark R, Graves T, Gulden CL, Alkan C, Bailey JA, Sahinalp C, Rocchi M, Haussler D, Wilson RK, Miller W, Schwartz S, Eichler EE.(2004) The structure and evolution of centromeric transition regions within the human genome. Nature.2004 Aug 19;430(7002):857-864.