2002 - 2003 Course Schedule

Summer 2002

Genetics 371: Introductory Genetics
Instructor: Steve Jackson
TAs: Maria Malzone, Kartik Varadarajan

Course Description:
Explores gene transmission, chromosome mapping, quantitative traits, population genetics, genetic analysis of biological processes. Emphasizes formal genetic mechanisms but includes some molecular techniques, such as restriction mapping, cloning, RFLP analysis. For biological sciences majors. Prerequisite: either BIOL 200 or BIOL 201.

Autumn 2002

Genome 351: Human Genetics - The Individual and Society
Instructors: Bob Braun, Kelly Owens
TA: Steve Voght

Course Description:
Principles of Mendelian inheritance as illustrated by human traits and diseases; chromosomes and sex determination; distribution of genes in populations; natural selection and evolution; counseling and genetic engineering; ethical issues. Appropriate for non-science majors.

Genome 371: Introductory Genetics
Instructors: Celeste Berg, Bonny Brewer, Anne Paul
TAs: Caroline Josefsson, Chitra Kotwaliwale, Laura Flinn

Course Description:
Explores gene transmission, chromosome mapping, quantitative traits, population genetics, genetic analysis of biological processes. Emphasizes formal genetic mechanisms but includes some molecular techniques, such as restriction mapping, cloning, RFLP analysis. For biological sciences majors. Prerequisite: either BIOL 200 or BIOL 201.

Genome 454: The Origins of Genetics
Instructor: Iris Sandler

Course Description:
Discovery and eventual triumph of Mendelism in the early twentieth century. Concepts of heredity from ancient times to the nineteenth century. Mendel's work and its rediscovery. Evidence contributing to cornerstone of classical genetics -- the chromosome theory of heredity. Prerequisite: either GENOME 351, GENOME 371, or GENOME 372.

Genome 490: Undergraduate Seminar
Instructor: Jon Gallant

Course Description:
Seminar for advanced undergraduate students engaged in individual research projects or those who wish to gain an understanding of genetic research by analysis of the primary literature. Assignments emphasize the rationale for research projects and the presentation and interpretation of research findings.

Genome 525: Current Literature in Human Genetics
Instructor: Clem Furlong

Course Description:
Medical Genetics Journal Club. Topics from current literature in human genetics. Students and faculty each present one topic per quarter. Credit/no credit only. Prerequisite: graduate or postdoctoral status.

Genome 550: Methods and Logic in Genetics
Instructors: Colin Manoil, Leo Pallanck

Course Description:
Critical reading and detailed discussion of genetics-related scientific research papers. Material emphasizes methodological and logical themes of importance in modern genetics, for example: origin of mutants, genetic epistasis, pulse labelling, and in vivo gene function. Prerequisite: first year Genome Sciences graduate students only.

Genome 551: Fundamentals of Biology
Instructor: Carol Sibley

Course Description:
Rudiments of basic biology with an emphasis on the role of DNA and protein analysis. This course is intended to introduce students with non-biology science backgrounds to the major concepts of biochemistry, genetics and molecular biology. Prerequisite: substantial background in chemistry, physics, mathematics, computer science, engineering, or related disciplines.

Genome 559: Introduction to Statistical and Computational Biology
Instructors: Bill Noble, Mark Rieder

Course Description: Rudiments of statistical and computational genomics. Emphasis on basic probability and statistics, introduction to computer programming and relevant web databases. This course is intended to introduce students with non-computer science backgrounds to the major concepts of programming and statistics. Prerequisite: substantial background in molecular and cellular biology, genetics, biochemistry, or related disciplines.

Genome 552: Genomics
Instructor: Debbie Nickerson

Course Description: Introduces students to the nature of genomes, the structure of chromosomes, the organization of sequences, and the diversity of these features in different species. Discusses current and newly emerging technologies for mapping and sequencing genomes, determining linkage of simple and complex disorders, and identifying variations in DNA. Formerly called MBT 510. Prerequisite: GENOME 551, GENOME 559 or equivalent.

Genome 590: Population Seminar
Instructor: Joe Felsenstein

Course Description:
Weekly presentation by participants of current literature and ongoing research in evolution, molecular evolution, evolutionary genetics of natural populations, human population genetics, and quantitative genetics applied to animal and plant breeding. Credit/no credit only. Prerequisite: GENOME 562 or permission of instructor.

Winter 2003

Genome 371: Introductory Genetics
Instructors: M.K. Raghuraman, Anne Paul
TAs: Brad Bavaro, Nicole Benkers, Jamie Klemp

Course Description:
Explores gene transmission, chromosome mapping, quantitative traits, population genetics, genetic analysis of biological processes. Emphasizes formal genetic mechanisms but includes some molecular techniques, such as restriction mapping, cloning, RFLP analysis. For biological sciences majors. Prerequisite: either BIOL 200 or BIOL 201.

Genome 372: Gene Structure and Function
Instructor: Janet Kurjan
TAs: Michele Hastings, Jon Ulmer, Laura Flinn

Course Description:
Explores the structure of genes and chromosomes, the mechanisms and control of transcription and translation, and the molecular mechanisms of mutation, recombination, transposition, and development. Intended for majors in biological sciences. Prerequisite: GENOME 371.

Genome 375: Debates in Genetics
Instructors: Carol Sibley, Mandy Schivell
TA: Allyson McCormick

Course Description: The course will use the original scientific literature as the basis for discussion of a range of genetic issues that impact society. Discussions will be student-led; evaluation will be based both on participation in class and on a research paper.

Genome 411: Gene Action
Instructor: Ann Reynolds
TA: Iyarit Thaipisuttikul

Course Description:
Molecular genetics: description of fundamental genetics processes such as mutation, repair, genetic exchange, recombination, and gene expression. Use of genetic strategies to analyze complex biological processes. Focus is on prokaryotic organisms. Prerequisite: BIOL 201; either CHEM 223, CHEM 237, or CHEM 335. Offered: jointly with MICROM 411

Genome 453: Genetics of the Evolutionary Process
Instructors: Peter Beerli, Mary Kuhner

Course Description:
Contributions of genetics to the understanding of evolution. Processes of mutation, selection, and random genetic events as they affect the genetic architecture of natural populations and the process of speciation. Emphasis on experimental data and observation, rather than mathematical theory. Prerequisite: either GENOME 371 or GENOME 372.

Genome 465 / 565: Advanced Human Genetics
Instructors: Mary-Claire King, Maynard Olson, Kelly Owens

Course Description:
Explores genetic analysis of naturally occurring variation in humans; origins and consequences of mutation, as mediated by selection, migration, population structure and drift; approaches to finding human disease genes and characterizing them at the molecular level; relevance of to other species to analysis of human genes. Prerequisite: GENOME 371; either GENOME 372 or BIOC 440.

Genome 540: Intro to Computational Molecular Biology
Instructor: Phil Green

Course Description:
Algorithmic and probabilistic methods for analysis of DNA and protein analysis. Students must be able to write computer programs for data analysis. Prior coursework in biology and probability highly desirable. Prerequisite: permission of instructor.

Genome 553: Genetic Analysis
Instructor: Celeste Berg

Course Description: Discusses methods for selectively removing, adding, or altering specific proteins, to identify and order genes in a pathway, define protein function, determine tissue and temporal requirements for gene function, and distinguish among competing hypotheses to explain biological phenomena. Formerly called GENET 551. Prerequisite: GENOME 371, GENOME 551 or equivalent.

Genome 554: Genomic Informatics
Instructor: Jim Thomas

Course Description: Introuduces students to the major methods for generating sequence alignments, practical use of web-based tools for identifying and analyzing sequences, the relationships between 3-dimensional protein structure and sequence divergence, and the meaning and interpretation of evolutionary trees in defining protein families and super-families. Prerequisite: GENOME 559 or equivalent.

Spring 2003

Genome 361: Genomes and Society
Instructor: Mandy Schivell
TAs: Shannon Murray, Kin Chan

Course Description:
Explores current technological advances in genome research and how these advances are impacting society. Topics include sequencing of the human genome, stem cell research, cloning, genetically modified foods, immunizations/public health, and genetic therapy. Appropriate for non-science majors.

Lecture: MWF 10:30 - 11:20, FSH 102
Quiz AA: M 1:30 - 2:20, HCK 316
Quiz AB: T 10:30 - 11:20, HCK 316
Quiz AC: T 1:30 - 2:20, HCK 316
Quiz AD: T 3:30 - 4:20, HCK 316

Genome 371: Introductory Genetics
Instructors: Leo Pallanck, Steve Jackson
TAs: Delia Pinto-Santini, Erin Smith, Trey Powers

Course Description:
Explores gene transmission, chromosome mapping, quantitative traits, population genetics, genetic analysis of biological processes. Emphasizes formal genetic mechanisms but includes some molecular techniques, such as restriction mapping, cloning, RFLP analysis. For biological sciences majors. Prerequisite: either BIOL 200 or BIOL 201.

Lecture: MWF 10:30 - 12:20, AND 223
Quiz AA: T 9:30 - 10:20, HCK 343
Quiz AB: T 10:30 - 11:20, HCK 343
Quiz AC: T 11:30 - 12:20, HCK 343
Quiz AD: T 12:30 - 1:20, HCK 343
Quiz AE: T 1:30 - 2:20, HCK 343
Quiz AF: T 2:30 - 3:20, HCK 343

Genome 466: Cancer Genetics
Instructor: Jim Thomas
TA: Kim Wachter

Course Description:
Focuses on three types of cancer-related genetics. DNA repair, mitotic recombination, chromosome loss and imbalance, and other aspects of genomic instability. Metastatic cancer as an example of natural selection and evolution. Yeast and nematodes as models for the study of cancer genetics. Prerequisite: either GENOME 371 or GENOME 372.

MWF 10:30 - 11:20, J-280

Genome 490: Undergraduate Seminar
Instructor: Mary Kuhner

Course Description:
Seminar for advanced undergraduate students engaged in individual research projects or those who wish to gain an understanding of genetic research by analysis of the primary literature. Assignments emphasize the rationale for research projects and the presentation and interpretation of research findings.

M 2:30 - 3:20, J-280

Genome 531: Genetics of Human Disease
Instructor: Peter Byers

Course Description:
Modern approaches to the identification of human disease genes permitted by their isolation. Functional conservation of proteins throughout eukaryotic evolution as an approach to their function in model systems such as somatic cell culture, transgenic mice, nematodes, Drosophila, and yeast. Prerequisite: second-year graduate student.

course cancelled for this quarter

Genome 541: Intro to Computational Molecular Biology II
Instructor: Phil Green, Joe Felsenstein

Course Description:
Computational methods for studying molecular evolution. Students must be able to write computer programs for data analysis. Prior coursework in biology and probability highly desirable Prerequisite: GENOME 540 or permission of instructor.

T Th 10:30 - 11:50, J-280

Genome 555: Proteomics
Instructor: Stan Fields

Course Description: The course will focus on current and emerging technologies and approaches for analyzing protein structure and function, protein:protein interactions, and whole-cell protein functions ("the proteome"). We will emphasize the application of these technologies in biology, biotechnology and medicine. Prerequisite: BIOC 440, GENOME 551 or equivalent.

T Th 9:00 - 10:20, K-350 second half of quarter only

Genome 556: Developmental Genetics
Instructor: Bob Braun

Course Description: Introduces students to developmental genetics in a range of organisms, emphasizing systems in which cellular, genetic, and molecular approaches have combined to make significant contributions to understanding developmental processes. Prerequisite: GENOME 553 or equivalent.

T Th 9:00 - 10:20, K-350 first half of quarter only

Genome 557: Meiosis
Instructor: Breck Byers

Course Description: A comprehensive consideration of meiotic mechanisms emerging from genetic and molecular analysis of model organisms focuses on the molecular basis of chromosomal synapsis, homologous recombination, and meiotic disjunction. The relationship of these mechanisms to the structure of the human genome and the analysis of complex traits are also considered.

course cancelled for this quarter

Genome 562: Population Genetics
Instructor: Joe Felsenstein

Course Description: Mathematical and experimental approaches to the genetics of natural populations, especially as they relate to evolution. Emphasis on theoretical population genetics. Prerequisite: permission of instructor.

MWF 12:30 - 1:20, J-280